Features：
Sequencing throughput is moderate
Based on the innovative semiconductor chip sequencing technology, the base sequence is obtained by detecting the pH change caused by the H + ion current generated during DNA replication in real time. Select different types of chips, a run can produce 10Gb ~ 60Gb data, which is ideal for independent clinical diagnostic laboratories.
Short Sequencing Time
The entire sequencing process takes only 2 hours, 3 runs per day can be completed, allowing clinical laboratory staff make full use of daily working hours and improve work efficiency.
Long Read Sequencing
Sequencing average read-length up to 200bp, capable of sequencing the whole length of plasma cell-free DNA.
Strong Extensibility
Without no need of changing the hardware of instrument host, it can complete application of different sequencing read lengths and data flux by only using sequencing chips with different fluxes.
PI Chip:
165 million reaction wells 15 to 18 non-invasive test samples
PII Chip:
660 million reaction wells 50 to 60 non-invasive test sample
Friendly Interface
Easy operating system, friendly interface design, training, proficient use of the system after one-day training.
Models：
Model | BioelectronSeq 4000 |
Sequencing Flux | PI chip: ≥ 10Gb; PII chip: ≥ 60Gb |
Sequencing Read Lengths | PI chip: 200 bases; PII chip:100 bases |
Effective Sequence Number | PI chip: ≥ 80 million; PII chip: ≥ 200 million |
Sequencing time | 2.5 hours |
Current Library solutions | Ion AmpliSeq™ Library Kit Ion Xpress™ Plus Fragment Library Kit Ion TargetSeq™ Exome Kit Ion Total RNA-Seq Kit |
Data analysis solutions | Torrent Browser allows users to remotely access instrument status and monitor sequencing process using network connection; Variety of clinical data analysis plugins can complete clinical personalized data analysis automatedly and rapidly |
Data Format | FASTQ, SFF, BAM and VCF etc. |
Gas supply | Connection: 0.25 in one-key connection accessory Pressure: 30 psi Composition: nitrogen (grade 4.8, 99.998% or better) |
Other connections | Ethernet: 1 GigE USB: 2x USB 2.0 |
Instrument computer hardware | Processor: Dual 8-core Intel® Xeon® Sandy Bridge Memory: 128 GB RAM FPGA: Dual Altera® Stratix® V GPU processor: 1x NVIDIA® Tesla® C2075 Storage: 11 TB (SSD and HDD) Operating system: Ubuntu® 11.10 |
Standard Configuration | 1. Gene Sequencer (BioelectronSeq 4000) 2. High-performance Server 3. Automatic Emulsion PCR Instrument (Ion OneTouch 2) 4.ES Magnetic Beads Nucleic Acid Purification Instrument (Ion OneTouch ES) 5. Multi Stage Pneumatic Control Valve 6. Sequencing Chip Centrifuge 7. Centrifuge Rotor |
Working environment (for indoor use only) | Temperature: 68 –77° F (20 –25° C); Humidity: 40–60%, noncondensing; Altitude: <6,500 ft (2,000 m); Clearances: 12 in (30.5 cm) in rear; 4 in (10 cm) on left side; 4 in (10 cm) on right side; 4 in (10 cm) from front edge of bench to sequencer bezel; 36 in (90 cm) aisle in front of bench for operator access |
Power Supply | AC220V, 50/60Hz,1100VA； AC110V, 60Hz(Optional, External transformer) |
Dimensions(W*D*H) | 618*750*507mm |
Net Weight | 60kg |
Package Size(W*D*H) | 1. Sequencer host: 900*610* 590mm 2. Sever: 1020* 860*920mm 3. ION OneTouch ES: 460*350* 330mm 4. ION OneTouch 2: 530*480*450mm 5. Ion torrent ionChip Minifuge; Ion Pronton rotor; Cord; and so on: 670*460* 540mm Total: 5 pcs (3 Cartons+2 Pallets) |
Gross Weight | 1. Sequencer host:60kg 2. Sever: 50kg 3. ION OneTouch ES: 8kg 4. ION OneTouch 2: 12kg 5. Ion torrent ionChip Minifuge; Ion Pronton rotor; Cord; and so on: 6kg |
Clinical Application：
Categories | Items |
Chromosomal Disease Test | Pre-production noninvasive gene test for chromosome aneuploidy (T21, T18, T13) Pre-production noninvasive gene test for chromosome micro-deletion/micro-duplication Gene test for chromosome abnormality |
Gene Test for Hereditary Disease | Gene test for hereditary deafness (227 genes+ mitochondrial genome) Gene test for 17 common genetic diseases Gene test for Duchenne/Becker muscular dystrophy (DMD/BMD) Gene test for clinical whole exome Test for individual whole exome |
Tumor-related Gene Test | Gene test for hereditary breast cancer/ovarian cancer (BRCA1/2) Gene test for 18 hereditary tumors (64 genes) Gene test for personalized medicine for lung cancer (12 genes) Gene test for personalized medicine for colorectal cancer(14,22 genes) Gene test for personalized medicine for breast cancer (10 genes) Gene test for comprehensive pan-cancer medicine (52 genes) Gene test for personalized chemotherapy medicine for tumor (10 genes) |
Microbial Gene Test | Gene test for infectious pathogenic microorganism |
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